The 2022 CNBC Disruptor 50 list: Meet the next generation of Silicon Valley

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In the tenth annual Disruptor 50 list, CNBC highlights private companies that grew through the ups and downs of the pandemic and are poised to meet increasing economic and consumer challenges.

All told, these firms have raised a half-trillion dollars in venture capital. At least 41 are unicorns, with valuations of $1 billion or more – 14 are valued at over $10 billion. But becoming a unicorn has become all too common, and as market volatility pressures valuations in both public and private markets, other stats stand out:

Forty of the companies have a social or environmental purpose that is core to their business model. Ten of this year’s Disruptors are from the logistics sector, tackling the broken global supply chain that has fueled four-decade high inflation. Eight are reducing costs in a bloated health-care system and reaching underserved populations. Several more are dedicated to the climate crisis. Nine of this year’s Disruptors have a female founder. Sixteen feature CEOs from racial and ethnic minorities.  

The 50 companies selected using the proprietary Disruptor 50 methodology have raised over $56 billion in venture capital, according to PitchBook, at an implied Disruptor 50 valuation of more than $552 billion.

1	Flexport	Overwhelming the supply chain bottleneck
2	Brex	The start-up world’s finance department
3	Lineage Logistics	On top of the global food supply’s temperature
4	Canva	The feature presentation
5	Guild Education	Work. Study.
6	Convoy	Trucking as we’ve known it stops here
7	Blockchain.com	Web3′s dot com
8	Stripe	Making the internet pay
9	Dapper Labs	The shot Michael Jordan and Kevin Durant are taking on decentralization
10	Pony.ai	Hand over the reins.
11	Checkout.com	A rival to the Stripe swipe
12	Chime	A challenger bank in a challenging fintech market
13	Discord	How digital natives converse
14	Flock Freight	Fully loaded
15	Medable	The virtual clinical trial
16	Truepill	The infrastructure for online pharmacy
17	Arctic Wolf	A cyber defender from up north
18	CloudTrucks	Big ideas for the Big Road
19	Maven Clinic	Putting women first in health
20	Monarch Tractor	1 driver. 8 tractors. All electric.
21	Fanatics	Taking sports merch into the metaverse
22	Tala	The world’s local lender
23	Anduril Industries	Engineering an autonomous military arsenal
24	Workato	Office work automated
25	Lacework	Cybercrime’s lie detector
26	Somatus	Kidney care without the dialysis centers
27	Gopuff	All your instant needs fulfilled
28	Virta Health	Don’t treat diabetes; reverse it.
29	Zipline	A life-saving drone, with a Walmart side hustle
30	CarbonCure	Carbon to concrete
31	Jüsto	Mexico’s answer to Walmart, and FreshDirect, and Gopuff
32	Biobot Analytics	A wastewater virus hunter
33	Airtable	The code for every knowledge worker
34	Databricks	The start-up world’s biggest data bet
35	DataRobot	A one-trillion predictions market maker
36	Relativity Space	An Elon Musk reusable rocket competitor
37	NEXT Insurance	Digital small business insurance
38	Ro	Planning to be a digital health survivor
39	Airspace	Critical on-demand delivery for the pandemic era
40	Thrasio	A consumer products giant for the digital age.
41	Cybereason	A bird’s eye view
42	BlocPower	Building net-zero cities
43	ŌURA	The one ring to rule wearables
44	MoonPay	The biggest celebrity bet on crypto
45	Zum	School bus magic
46	Exotec	France’s warehouse robot unicorn
47	Plaid	A bridge from fintech to bank
48	Cityblock Health	Healthtech for low-income America
49	Impossible Foods	From plant-based fad to fixture
50	Envoy	Back to the office of the future

These are the top 25 enterprise technology startups powering the economy

CNBC’s first-ever Top Startups for the Enterprise list highlights startups powering digital transformation, attracting strategic investments and potentially drawing acquisition interest. These are up-and-coming companies built by ambitious, creative, and innovative entrepreneurs who specifically set out to develop the latest technology in business intelligence, IT, cloud, big data, and cybersecurity as companies in all sectors of the economy allocate increasing levels of spending to technology.

The 25 startups selected using a proprietary methodology have raised over $14 billion in venture capital, according to PitchBook, at an implied collective valuation of more than $147 billion. Most of the companies on the unranked list use a combination of AI, machine learning, and cloud computing as critical drivers of their business models, and more than a third of the companies provide cybersecurity solutions.

Well-funded firms like these are in a particularly good position to meet the needs of large enterprises that are doubling down on emerging opportunities, despite the uncertain economic climate.

COMPANY	HEADQUARTERS	FOUNDED	CATEGORY
ABNORMAL SECURITY	San Francisco	2018	Cybersecurity
AERA TECHNOLOGY	Mountain View, California	2017	Big Data
ANCHAIN.AI	San Jose, California	2018	Fintech
ARCTIC WOLF	Eden Prarie, Minnesota	2012	Cybersecurity
AVIATRIX	Santa Clara, California	2014	Cybersecurity
BALBIX	San Jose, California	2015	Cybersecurity
BIGID	New York City	2016	Cybersecurity
BREX	San Francisco	2017	Fintech
CANVA	Sydney, Australia	2012	Design
COGNITE	Oslo, Norway	2017	Big Data
CRIBL	San Francisco	2017	Big Data
DATABRICKS	San Francisco	2013	Big Data
DREMIO	Santa Clara, California	2015	Big Data
EIGHTFOLD.AI	Santa Clara, California	2016	HR Tech
FORETHOUGHT	San Francisco	2018	Customer Relationship Management (CRM)
HARNESS	San Francisco	2016	Software development
JUPITERONE	Morrisville, North Carolina	2020	Cybersecurity
LACEWORK	San Jose, California	2015	Cybersecurity
MEDABLE	San Francisco	2015	Big Data
MONTE CARLO	San Francisco	2019	Big Data
PAPAYA GLOBAL	Herzliya, Israel	2016	HR Tech
SNYK	Boston	2015	Cybersecurity
UJET	San Francisco	2015	Customer Relationship Management (CRM)
VERBIT	Tel Aviv, Israel	2017	Automation
WORKATO	Mountain View, California	2013	Automation